Available multiple sequence alignment views: Expanded: This view shows residue conservation: red for conserved residues, blue for columns with no gaps. Gray is for columns containing gaps. Where less than 50% of the sequences contain gaps, they are shown in gray uppercase, greater than 50% will be gray lowercase. Compact: This view is similar to Expanded, but the unaligned columns are compressed into the bracket form: [x], where x denotes the number of residues for a sequence in the unaligned range. Plain Text: Simple text with gaps (traditional COBALT view).
Multiple sequence alignment columns with no gaps are colored in blue or red. The red color indicates highly conserved columns and blue indicates less conserved ones. The Conservation Setting can be used to select a threshold for determining which columns are colored in red. Numerical setting: The number is the relative entropy threshold, in bits, that must be met for an alignment column to be displayed in red. A larger number indicates higher degree of conservation. The relative entropy is computed as: ∑i fi log2 ( fi / pi), where i is residue type, fi is residue frequency observed in the multiple alignment column, and pi is the background residue frequency. Identity setting: Only columns with one residue type will be colored in red.
XP_038935520.1 1 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLL 80 NP_954548.1 1 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLL 80 NP_001333673.1 1 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLL 80 NP_659060.1 1 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPRRLL 80 XP_009304967.1 1 MELSAIGEQVFAVESITKKRVRKGHVEYLLKWKGWPPKYSTWEPEEHILDPRLVLAYEEKEQKERSVVWRKRGRKPKRLH 80 XP_038935519.1 1 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLL 80 XP_038935520.1 81 LQESAAPDVLQAT GDWEPVEQPPEEE -EADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAE 147 NP_954548.1 81 LQESAAPDVLQAT GDWEPVEQPPEEE AEADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAE 148 NP_001333673.1 81 LQEPPAPDVLQAA GEWEPAAQPPEEE ADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAE 148 NP_659060.1 81 LQESAAPDVVQTP GDWEPMEQAPEEE AEADLTNGPPPWTPTLPSSEVTVTDITANSVTVTFREAQAAE 148 XP_009304967.1 81 EQRSIYTMDLRST[43]EEWDRREEEDDDE[38]TESEAMSLPEDWSPVMGPEEVMVTDITINSLTVTFREALVAR 229 XP_038935519.1 81 [34]LQESAAPDVLQAT GDWEPVEQPPEEE AEADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAE 182 XP_038935520.1 148 GFFRDRSGKL 157 NP_954548.1 149 GFFRDRSGKL 158 NP_001333673.1 149 GFFRDRSGKF 158 NP_659060.1 149 GFFRDRNEKL 158 XP_009304967.1 230 GFFSSWEMEI 239 XP_038935519.1 183 GFFRDRSGKL 192